Endocrine Abstracts

Introduction: The SNP rs7578597 (Thr1187Ala) of THADA gene was identified in GWA studies as a novel type 2 diabetes risk locus. Nevertheless, subsequent studies of this SNP effect have been inconclusive. In some studies, rs7578597 has been associated with insulin secretion but no significant correlation with type 2 diabetes has been reported. Product of THADA gene is considered to be involved in apoptosis. Whether rs7578597 affects insulin secretion throught the apoptosis of p...

Introduction: Vaspin, identified as a novel insulin-sensitizing adipokine, is suggested to be dysregulated in T2DM patients with loss of association between circulating vaspin levels, BMI and insulin resistance (IR). The aim of this study was to examine whether restrictive bariatric surgery in severely obese women with T2DM leads to a realignment of vaspin and metabolic factors early following surgery and before complete resolution of diabetic status.Met...

Introduction: Bariatric surgery has been proved to be the most effective treatment for type 2 diabetes mellitus (T2D). Post-operative improvement in insulin sensitivity seems to be partly independent of weight loss and may be affected by changes in incretin secretion. Previous studies reported that the glucose-dependent insulinotropic polypeptide (GIP)-induced enhancement of fat stores may lead to increased insulin resistance. We determinated the effect of laparoscopic adjusta...